ABSTRACT

https://doi.org/10.5005/jp-journals-10002-1277
World Journal of Endocrine Surgery
Volume 12 | Issue Suppl 1 | Year 2020

17th Biennial Congress of the Asian Association of Endocrine Surgeons—AsAES 2020

Corresponding Author:

5th to 7th March 2020

Melbourne, Australia

Website: http://asaes2020.org/

Chairman: Akira Miyauchi

Congress President and Scientific Convenor: Julie Miller, Australia

1. Multi-modality Treatment of Anaplastic Thyroid Cancer: Outcomes of Yonsei Protocol

Seok-Mo Kim¹, Yong S Lee², Hojin Chang³, Hee J Kim⁴, Soo Y Kim⁵, Hang-Seok Chang⁶, Cheong S Park⁷

^1–7Department of Surgery, Thyroid Cancer Center, Gangnam Severance Hospital, Institute of Refractory Thyroid Cancer, Yonsei University College of Medicine, Seoul, Korea

Introduction

Materials and methods

Results

Conclusion

2. Usefulness of Stereotactic Radiotherapy for Locoregional Recurrence and Metastatic Thyroid Cancer

Takayuki Ishigaki¹, Takashi Uruno², Kiminori Sugino³, Takashi Kazama⁴, Isao Tabei⁵, Hiroshi Takeyama⁶, Koichi Ito⁷

¹Department of Surgery, Ito Hospital, Tokyo, Japan; Department of Breast and Endocrine Surgery, Jikei University School of Medicine, Tokyo, Japan^2,3,7Department of Surgery, Ito Hospital, Tokyo, Japan^4,6Department of Breast and Endocrine Surgery, Jikei University School of Medicine, Tokyo, Japan⁵Department of Breast and Endocrine Surgery, Jikei University School of Medicine, Tokyo, Japan; Department of Surgery, Jikei University Daisan Hospital, Tokyo, Japan

Purpose

Materials and methods

Results

Conclusion

3. Perioperative Management of Pheochromocytoma: Experience from Australia and New Zealand

A Papachristos¹, T Cherry², M Nyandoro³, D Lisewski⁴, S Stevenson⁵, P Mercer⁶, S Subramaniam⁷, S Sidhu⁸, M Sywak⁹, J Miller¹⁰

^1–10The Royal Melbourne Hospital, Fiona Stanley Hospital, Christchurch Hospital, Royal North Shore Hospital, Australia, New Zealand

Purpose/Introduction

Materials and methods

Results

Conclusion

4. Calcifications Formation on Ultrasonography after Fine Needle Aspiration in Benign Thyroid Nodules

Yi-Jhih Tsai¹, Shih-Ming Huang²

¹Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan²Department of Surgery, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan; Department of Surgery, National Cheng Kung University Hospital, Tainan, Taiwan

Purpose

Materials and methods

Results

Conclusion

5. Thyroid Function after Lobectomy for Papillary Thyroid Cancer

S Shizuka¹, H Kiyomi², O Takahiro³, H Kento⁴, K Hidenori⁵, F Mikiko⁶, Y Yusaku⁷, N Eichiro⁸, O Yoko⁹, S Akiko¹⁰

¹Tokyo Women’s Medical University, Tokyo, Japan^2–10Department of Breast and Endocrine Surgery, Tokyo Women’s Medical University, Tokyo, Japan

Purpose/Introduction

Materials and methods

Results

Conclusion

6. Prospective Cohort Study of Objective Cardiac Changes in Pheochromocytoma and Paraganglioma and their Reversal following Curative Surgery

KMM Vishvak Chanthar¹, Gaurav Agarwal², Adhitya Kapoor³, Roopali Khanna⁴

^1–4Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

Purpose of the study

Materials and methods

Results

Discussion

Annexure

**Table 1**: Comparison of echocardiographic baseline parameters between exposed and unexposed groups
	PCC/PGL n = 15	Unexposed n = 15	p value
Septal wall thickness (mm)	11 ± 1.4	9.2 ± 1.3	0.001
Poster wall thickness (mm)	12 ± 2.5	9.1 ± 0.9	0.0002
Aorta diameter (mm)	31 ± 4	28 ± 3.6	0.039
LVEDD (mm)	42 ± 2.4	45.7 ± 3.2	0.001
LVEDV (mL)	91 ± 12	72.3 ± 9.3	0.0001
LVESV (mL)	34.4 ± 9.5	30.2 ± 4.3	0.130
LVEF (%)	58.4 ± 6	60 ± 4	0.39
E/A	1.6 ± 0.7	1.08 ± 0.28	0.012
Septal e’	0.08 ± 0.03	0.11 ± 0.02	0.003
Lateral e’	0.13 ± 0.03	0.16 ± 0.03	0.010

**Table 2**: Comparison of speckle tracking echo baseline parameters between exposed and unexposed groups
	PCC/PGL n = 15	Unexposed n = 15	p value
Longitudinal myocardial strain (%)	−14.4 ± 3	−21.2 ± 2	0.0001
Circumferential myocardial strain (%)	−25.3 ± 3.2	−22 ± 2.1	0.002

**Table 3**: Echocardiographic parameters in PCC/PGL patients (n = 15) and their changes after surgical cure
Parameters	At diagnosis	After α-blockade	Postoperatively		p value*
Parameters	At diagnosis	After α-blockade	7–10 days	3 months	p value*
Septal thickness (mm)	11 ± 1.4	10.9 ± 1.7	10.6 ± 1.5	9.8 ± 1.2	0.017
Poster wall thickness (mm)	12 ± 2.5	11 ± 1.7	10.3 ± 1.6	9.9 ± 1.5	0.006
LVEDD (mm)	42 ± 2.4	43.3 ± 3.1	45.6 ± 4	47.2 ± 3.1	0.001
LVEDV (mL)	91 ± 12	96 ± 10.5	98.1 ± 13	102 ± 13.2	0.02
LVESV (mL)	27 ± 9.5	32.3 ± 7.3	38.2 ± 8.4	41 ± 4.3	0.0001
LVEF (%)	58.4 ± 6	59.7 ± 8.3	61.9 ± 3.8	64 ± 4.5	0.007
E/A	1.08 ± 0.28	1.3 ± 0.2	1.3 ± 0.2	1.4 ± 0.3	0.005
Septal e′	0.08 ± 0.03	0.07 ± 0.01	0.05 ± 0.02	0.04 ± 0.02	0.0002
Lateral e′	0.13 ± 0.03	0.12 ± 0.02	0.11 ± 0.01	0.09 ± 0.02	0.0002

* p value calculated between echo parameters at diagnosis and at 3 months postsurgery

**Table 4**: Speckle tracking echo parameters in PCC/PGL patients (n = 15) and their changes after surgical cure
	At diagnosis	After α-blockade	Postoperatively		p value*
	At diagnosis	After α-blockade	7–10 days	3 months	p value*
Longitudinal myocardial strain (%)	−14.4 ± 3	−15.6 ± 1.1	−17.1 ± 1.4	−19.2 ± 2	0.0001
Circumferential myocardial strain (%)	−25.3 ± 3.2	−24.6 ± 1.2	−23.2 ± 1.3	−22.1 ± 2	0.0027

* p value calculated between echo parameters at diagnosis and at 3 months postsurgery

7. Prediction of Vocal Cord Paresis and Recovery after Loss of Signal during Thyroid Surgery

C Nylén¹, M Lundgren², A Aniss³, A Glover⁴, SB Sidhu⁵, M Sywak⁶

¹Department of Endocrine Surgery, Royal North Shore Hospital, St Leonards, New South Wales, Australia; Department of Molecular Medicine and Surgery, Endocrine Surgery Unit, Karolinska Institutet, Stockholm, Sweden²Department of Molecular Medicine and Surgery, Endocrine Surgery Unit, Karolinska Institutet, Stockholm, Sweden³Department of Endocrine Surgery, Royal North Shore Hospital, St Leonards, New South Wales, Australia^4–6Department of Endocrine Surgery, Royal North Shore Hospital, St Leonards, New South Wales, Australia; Sydney Medical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia

Purpose/Introduction

Materials and methods

Results

Conclusion

8. Epithelial–Mesenchymal Transition and its Association with PD-L1 and CD8+ T Cells in Thyroid Cancer

MJ Aghajani¹, TL Roberts², T Yang³, P DeSouza⁴, N Niles⁵

^1–5Western Sydney University, Ingham Institute, Australia

Purpose

Materials and methods

Results

Conclusion

9. CRISPR/Cas9 Mediated BRAF Mutation and its Influencing Factors in Papillary Thyroid Carcinoma Cells

Qiang Zhang¹, Xianying Meng², Yaoqi Wang³, Jifan Hu⁴, Guang Chen⁵

¹Department of Thyroid Surgery, The First Hospital of Jilin University, Changchun, Jilin, China; Department of Endocrinology, Stanford University, Stanford, California, USA^2,3,5Department of Thyroid Surgery, The First Hospital of Jilin University, Changchun, Jilin, China⁴Department of Endocrinology, Stanford University, Stanford, California, USA

Background and objective

Materials and methods

Results

Conclusion

Keywords

10. Synergistic Anti-cancer Effect of Histone Deacetylase Inhibition and Blockade of the Glycolytic Pathway

Hojin Chang¹, Soo Y Kim², Hee J Kim³, Chiyung Lim⁴, Taeil Yoon⁵, Yong S Lee⁶, Cheong S Park⁷, Hang-Seok Chang⁸

^1–3,6–8Department of Surgery, Thyroid Cancer Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea⁴National Health Insurance Service, Ilsan Hospital, Goyang-si, Gyeonggi-do, Korea⁵The 21st Century Women’s Clinic, Suwon, Gyeonggi-do, Korea

Background

Materials and methods

Results

Discussion and conclusion

11. Two Distinct E3 Ligases Target Thyroid Transcription Factor 1 for its Ubiquitination and Degradation in Thyroid Follicular Normal Epithelial and Carcinoma Cells, Respectively

Jia Liu

Jilin Province, China

Background

Materials and methods

Results

Conclusion

12. Comprehensive Gene Expression Profile between Follicular Thyroid Cancer and Benign Thyroid Tumor

M Iwadate¹, Y Matsumoto², S Hasegawa³, S Suzuki⁴, H Mizunuma⁵, K Nakano⁶, S Suzuki⁷

^1–7Department of Thyroid and Endocrinology, Fukushima Medical University, Fukushima, Japan

Introduction

Materials and methods

Results

Conclusion

13. Quality of Life Outcomes after Thyroidectomy for Malignant and Benign Thyroid Disease

NDA Blefari¹, CW Rowe², J Weigner³, R Carroll⁴, C Bendinelli⁵, CJ O’Neill⁶

^1–6Division of Surgery, John Hunter Hospital, Newcastle, New South Wales, Australia; School of Medicine and Public Health, University of Newcastle, New South Wales, Australia; Hunter Medical Research Institute, Newcastle, New South Wales, Australia

Purpose

Materials and methods

Results

Conclusion

14. Surgeon-performed Ultrasound in Assessing Thyroid Nodules using ACR-TIRADS and Total Malignancy Score: A Validation Cross-sectional Study

ASA Muhammed¹, SN Suhaimi², MNH Latar³, R Singh⁴

^1–4Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia

Purpose

Materials and methods

Results

Conclusion

15. Clinicopathological Evaluation of Papillary Thyroid Microcarcinomas

Kimihito Fujii

Japan

Background and aims

Materials and methods

Results

Discussion

16. How Big is Safe for Surveillance? The Impact of Tumor Size on Lymphovascular Invasion

SP Cheng¹, CL Liu², JJ Lee³, TP Liu⁴, PS Yang⁵, CY Kuo⁶

^1–6MacKay Memorial Hospital and Mackay Medical College, Taiwan

Introduction

Materials and methods

Results

Conclusion

17. Surgical Treatment of Functioning Pulmonary Metastases from Parathyroid Carcinoma

T Okamoto¹, K Horiuchi², Y Omi³, Y Yoshida⁴, M Kanzaki⁵, K Abe⁶, S Sakai⁷, K Karasawa⁸, Y Nagashima⁹

^1–4Department of Breast and Endocrine Surgery, Tokyo Women’s Medical University, Tokyo, Japan⁵Department of Thoracic Surgery, Tokyo Women’s Medical University, Tokyo, Japan^6,7Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women’s Medical University, Tokyo, Japan⁸Department of Radiation Oncology, Tokyo Women’s Medical University, Tokyo, Japan⁹Department of Surgical Pathology, Tokyo Women’s Medical University, Tokyo, Japan

Purpose

Materials and methods

Results

Conclusion

18. Maintaining TSH %3C; 2.0 mU/L without Thyroxine is Difficult after Lobectomy for Low-risk Thyroid Cancer

SY Liu¹, X Lo², EK Ng³

^1–3Department of Surgery, Division of Endocrine Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong

Purpose/Introduction

Materials and methods

Results

Conclusion

19. Photoacoustic Spectral Response for Thyroid Nodule Diagnosis: A Pilot Study

Paul M Jacob¹, Abhijeet Gorey², Reetu John³, Marie T Manipadam⁴, MS Ansari⁵, George CK Chen⁶, Srivathsan Vasudevan⁷

^1,3,4Christian Medical College, Vellore, Tamil Nadu, India²Discipline of Electrical Engineering, Indian Institute of Technology, Indore, Madhya Pradesh, India⁵LPSD, Raja Ramanna Centre for Advanced Technology, Indore, Madhya Pradesh, India⁶BC Photonics Technological Co., Richmond, Canada⁷Discipline of Electrical Engineering, Indian Institute of Technology, Indore, Madhya Pradesh, India; Centre for Biosciences and Biomedical Engineering, Indian Institute of Technology, Indore, Madhya Pradesh, India

Purpose

Materials and methods

Results

Conclusion

Fig. 1: Amplitude at different frequencies in the acoustic signal generates a unique spectral signature for FVPTC and appears related to mechano-biological properties

Fig. 2: Frequency spectra of intrinsic mode function 3 for malignant, colloid cyst and benign hyperplasia could be differentiated using empirical mode decomposition

20. A Retrospective Evaluation of the Timing of Distant Metastasis Occurrence in Papillary Thyroid Cancer

Y Noguchi

Noguchi Thyroid Clinic and Hospital Foundation, Japan

Purpose/Introduction

Materials and methods

Results

Conclusion

21. “Shaver Debulking” to Aid Thyroidectomy: Obviating the Need for Sternotomy in Retro-sternal Goiter

S Kleid

Peter MacCallum Cancer Centre, Melbourne, Australia

Purpose/Introduction

Materials and methods

Results

Conclusion

22. Mini-sternotomy for Thyroid Surgery

S Flatman¹, M Magarey², M Cypel³, J Freeman⁴

^1,2Department of Head and Neck Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia³Department of Thoracic Surgery, University of Toronto, Toronto, Canada⁴Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Canada

Oral (Video) Presentation

Learning points

Key steps

23. Outcomes of Endoscopic Cauterization Treatments and Open Fistulectomy for Pyriform Sinus Fistula

H Masuoka¹, A Miyauchi²

^1,2Department of Surgery, Kuma Hospital, Japan

Introduction

Materials and methods

Results

Conclusion

24. Cryopreservation of Parathyroid Tissue: Why and How to Establish a Local Service

EC Moore¹, A Siperstein², S Gupta³

^1–3The Cleveland Clinic, Cleveland, Ohio, USA

Purpose

Materials and methods

Results

Conclusion

25. Laparoscopic vs Robotic Adrenalectomy: Clinical Series from a Single Center

Murat Ozdemir¹, UC Can², Berk Sertoz³, Ozer Makay⁴

Introduction

Materials and methods

Results

Conclusion

26. Microanatomic Classification of Arterial Branches of Superior Parathyroid Gland from Inferior Thyroidal Artery

Keunchul Lee¹, Jin Yoon², Hyeong W Yu³, Su-Jin Kim⁴, Young J Chai⁵, June Y Choi⁶, Kyu E Lee⁷

^1–3,6Department of Surgery, Seoul National University Bundang Hospital, South Korea^4,7Department of Surgery, Seoul National University Hospital, South Korea⁵Department of Surgery, Seoul National University Boramae Medical Center, South Korea

Purpose/Introduction

Materials and methods

Results

Conclusion

Fig. 1: Classification of superior parathyroid branch from inferior thyroidal artery

27. Is Fukushima’s Thyroid Cancer Occurred Due to the Radiation Effect or Screening Effect?

S Suzuki¹, M Iwadate², Y Matsumoto³, S Hasegawa⁴, Suzuki Sa⁵, K Nakano⁶, H Mizunuma⁷

^1–7Department of Thyroid and Endocrinology, Fukushima Medical University School of Medicine, Japan

Introduction

Materials and methods

Results

Conclusion

28. Does Thyroidectomy Positively Affect the Quality of Voice in the Absence of Nerve Injury?

S Garg¹, LE Enny², Sasi Mouli³, M Shreyamsa⁴, KR Singh⁵, P Ramakant⁶, AK Mishra⁷

^1–7Department of Endocrine Surgery, King George’s Medical University, Lucknow, Uttar Pradesh, India

Introduction

Materials and methods

Results

Conclusion

29. The Timing and Location of Recurrence in Patients with Reoperation for the Neck Node Recurrence of Papillary Thyroid Carcinoma

Hyeung K Kim¹, Eun J Ha², Inhwa Lee³, Jeonghun Lee⁴, Euy Y Soh⁵

^1,3–5Department of Surgery, Ajou University School of Medicine, Suwon, Korea²Department of Radiology, Ajou University School of Medicine, Suwon, Korea

Purpose/Introduction

Materials and methods

Results

Conclusion

**Table 1**: The timing to reoperation due to neck node recurrence
Duration (year)	<1	1–2	2–5	5–10	%3E;10
n (%)	20 (18.1)	28 (25.4)	43 (39.1)	17 (15.5)	2(1.8)
Accumulate n (%)	20 (18.1)	48 (43.6)	91 (82.7)	108 (98.2)	110 (100)
Time to reoperation, median (m) min.–max. (m)				28 (4–186)
Duration of f/u, median (m) min.–max. (m)				68 (8–198)

**Table 2**: Retrospective CT review of reoperation patients due to neck node recurrence
	Initial CT scan		Follow-up CT scan	n (%)
	Initial finding	Review finding	Follow-up CT scan	n (%)
Newly developed lymph nodes	(−)	(−)	(+)	21 (19.1)
Missed diagnosis; false-negative	(−)	(+)	(+)	42 (38.2)
Recur after operation	(+)	(+)	(+)	33 (30.0)
Remnant lymph node after operation	(+)	(+)	(+)	14 (12.7)

**Table 3**: The details of cases in incomplete operation in patients with neck node recurrence (n = 14)
No.	Sex	Age	Initial surgery	Recurrence site	RFS	ATA risk stratification	Serum TG status*	Postoperative RAITx (mCi)	Response to therapy	Reason
1	F	45	Total thyroidectomy with CCND	Rt. level 4	61	Intermediate risk	Continuous elevation	200/250/300 /300	Excellent response	Insufficient operation
2	M	50	Total thyroidectomy with mRND, Lt.	Lt. level 3	25	Intermediate risk	No elevation	150	Excellent response	Insufficient operation
3	M	43	Total thyroidectomy with mRND, Rt.	Rt. Para-esophageal LNs.	12	Intermediate risk	Continuous elevation	150	Excellent response	Insufficient operation
4	M	41	Total thyroidectomy with mRND, Lt.	Lt. level 2	18	Intermediate risk	No elevation	150	Excellent response	Insufficient operation
5	F	63	Total thyroidectomy with mRND, both.	Lt. level 3	22	High risk	Continuous elevation	150	Excellent response	Insufficient operation
6	F	31	Total thyroidectomy	Rt. level 7	59	High risk	Continuous elevation	30	Excellent response	Difficult to approach
7	M	47	Total thyroidectomy with mRND, both.	Both supra-clavicular LNs	36	High risk	Continuous elevation	250/250/200	Structural incomplete	Difficult to approach
8	F	31	Total thyroidectomy with mRND, both.	Rt. level 7	17	Intermediate risk	Continuous elevation	150/150	Excellent response	Difficult to approach
9	F	32	Total thyroidectomy with mRND, both.	Lt. level 1	16	Intermediate risk	Continuous elevation	200/100	Excellent response	Difficult to approach
10	F	23	Total thyroidectomy with mRND, both.	Rt. supraclavicular LNs	5	Intermediate risk	Continuous elevation	200	Structural incomplete	Difficult to approach
11	F	31	Total thyroidectomy with mRND, both.	Rt. supraclavicular LNs	6	Intermediate risk	Continuous elevation	150	Biochemical incomplete	Difficult to approach
12	M	36	Total thyroidectomy with mRND, both.	Between CCA and IJV on level II	11	Intermediate risk	Continuous elevation	150	Excellent response	Difficult to approach
13	M	22	Total thyroidectomy with mRND, both.	Suprahyoid bone	12	High risk	Continuous elevation	100	Excellent response	Difficult to approach
14	M	47	Total thyroidectomy with mRND, Rt.	Between CCA and IJV on level II	20	Intermediate risk	No elevation	150	Excellent response	Difficult to approach

* Serum TG status at recurrence

30. Therapeutic Outcomes of Nerve Injury in Surgery for Papillary Thyroid Carcinoma

Mehak Mahipal¹, Sujith Wijerathne², Lim Chwee Ming³, Thomas Loh⁴, Rajeev Parameswaran⁵

^1,2,5Department of Endocrine Surgery, National University Hospital, Singapore^3,4Department of Head and Neck Surgery, National University Hospital, Singapore

Purpose

Materials and methods

Results

Conclusion

31. Bio 3D Tissue Printing of Parathyroid Glands: Survival Experiment in the Laboratory and after Animal Implantation

Hyeong W Yu¹, June Y Choi², Kyu E Lee³, Byoung S Kim⁴, Jae Y Lee⁵, Jinah Jang⁶, Dong-Woo Cho⁷

^1,2Department of Surgery, Seoul National University Bundang Hospital, South Korea³Department of Surgery, Seoul National University Hospital, South Korea^4–7Department of Mechanical Engineering, Pohang University of Science and Technology, South Korea

Purpose/Introduction

Materials and methods

Results

Conclusion

Fig. 1: In laboratory studies, both groups survived for 7 days. In animal experiments, the optical density score increased gradually in both groups, and the printing group score was higher than the naive group

32. “One Stop Thyroid Clinic”: A More Cost-effective and Faster Management for Singapore

RM Singaporewalla

Department of Surgery, Endocrine Surgical Service, Khoo Teck Puat Hospital, Singapore

Purpose

Materials and methods

Results

Conclusion

Fig. 1: Patient movement to and fro between different specialists (ping-pong effect)

**Table 1**: Cost-efficacy of one stop thyroid clinic (numbers in brackets—traditional costs)
Key markers
Time to work-up and review biopsy (FNAC) result	Average 8.21 days	Range 1–16 days
Cost of quadruple-assessment in ONE-STOP clinic	Subsidized patient—$192 ($402)	Private patient—$488 ($1,018)
Bethesda 1 result (inadequate/insufficient FNAC)	5 out of 320 patients	1.56%
Clinico-pathological correction with Bethesda and TIRADS (2015–2018)	Concordance rate benign lesions (TIRADS 2) 100%	TIRADS 2 lesions not to be subjected to FNAC

33. Improving Results of Primary Hyperparathyroidism Treatment: Additional Localizing Studies vs Bilateral Neck Exploration

IV Sleptsov¹, RA Chernikov², YN Fedotov³, AN Bubnov⁴, TV Borisenko⁵, KY Novokshonov⁶, AA Uspenskaya⁷, YV Karelina⁸, VA Makarin⁹, IK Chinchuk¹⁰, EA Fedorov¹¹, NI Timofeeva¹², YN Malyugov¹³, NA Gorskaya¹⁴, AA Semenov¹⁵, IV Sablin¹⁶, TS Pridvizhkina¹⁷, DV Rebrova¹⁸, AS Sleptsova¹⁹

^1–19St Petersburg State University, North-West Center of Endocrinology and Endocrine Surgery, Russia

Aim

Materials and methods

Results

Conclusion

34. Active Surveillance for Low Risk PTMC—Characteristics of Chinese Patients

Luo Bin

Department of General Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China

Purpose

Materials and methods

Results


	n	Age (year)	Size (mm)	w/thyroiditis (%)	F/U (m)	Surgery
FNAC-confirmed	52	38 (24–61)	6.8	38	35	7 (13%)
TIRADS-5	73	41 (25–66)	5.1	16	29	0
Total	125	40	5.8	25	30	7 (5.6%)

Conclusion

35. Optimal Surgical Management of Renal Hyperparathyroidism

AJ Krige¹, MA Bochner², J Kollias³, RJ Whitfield⁴, JMM Bingham⁵

^1–5Royal Adelaide Hospital, Australia

Secondary and tertiary hyperparathyroidism are major complications of chronic renal failure, and can persist following renal transplantation. The optimal surgical treatment of renal hyperparathyroidism is uncertain. We examined our experience with an audit of consecutive cases at our center. In a single-center retrospective audit of a 10-year period, we compared outcomes between total parathyroidectomy with autograft and subtotal parathyroidectomy. The theater database ORMIS was utilized to capture all parathyroidectomies over the study period, with this list filtered for operations performed for renal hyperparathyroidism. Patient records were accessed to determine reason for referral (secondary or tertiary hyperparathyroidism), dialysis or transplant status, type of operation, weight of resected tissue, duration of postoperative calcium infusion, length of stay, calcium and parathyroid hormone (PTH) trends and complications. These data were compared between groups, with exclusion of MIP and re-exploration operations. Of all patients undergoing parathyroidectomy for renal hyperparathyroidism (n = 83), the majority were performed for tertiary hyperparathyroidism. Approximately half the patients had functioning transplants or required definitive management of hyperparathyroidism before being waitlisted for transplantation. Fifty five patients underwent subtotal parathyroidectomy and 23 had a total parathyroidectomy with autograft, with the remainder undergoing MIP or re-exploration. Length of stay was significantly less in the subtotal parathyroidectomy group, with a trend toward shorter duration of postoperative calcium infusion. There was no significant difference in the postoperative calcium and PTH levels over time. Subtotal parathyroidectomy is not inferior to total parathyroidectomy with autograft, and may result in shorter duration of postoperative calcium infusion and length of stay.

36. Improvement of the Eighth Edition of the Tumor-node-metastasis Classification by Subclassifications of Tumor Extension and Node Metastases in Papillary Thyroid Cancer

Y Ito¹, A Miyauchi², M Kihara³, H Masuoka⁴, T Higashiyama⁵, A Miya⁶

^1–6Department of Surgery, Kuma Hospital, Kobe, Japan

We investigated how to improve the 8th edition of TNM classification (TNM-8th) to predict prognoses more accurately by enrolling 5,683 papillary carcinoma (PTC) patients, who underwent surgery between 1988 and 2005 (median follow-up period, 15 years). We subdivided tumor extension (T4a) into two categories: T4a1, extending to the tracheal adventitia and cartilage, esophageal muscle layer, recurrent laryngeal nerve, and cricothyroid and inferior constrictor muscles, and T4a2, extending to other organs such as the tracheal and esophageal mucosa, jugular and brachiocephalic veins. We subdivided N factor into two categories: N1, size ≤3 cm, and N2, size >3 cm. The 20-year cause-specific survival (CSS) rates were 99.3, 93.4%, 82.6%, and 11.3% for patients with stages I, II, III, and IVB, respectively. In patients <55 years, although M0, N2 and/or T4a2 patients had the similar CSS to stage II patients. Therefore, they were upstaged to revised stage (restage) II. In patients ≥55 years, since stage III patients with T4a1 showed the similar CSS to stage II patients, they were downstaged to restage II. In contrast, N2 patients ≥55 years were upstaged to restage III, because they had a similar CSS to T4a2 patients. The number of restage III patients decreased from 406 to 136 and 20-year CSS rate became poorer, at 69.5%. In contrast, the number of restage II patients increased from 403 to 798, but the 20-year CSS rate was similar, at 91.8%. These findings suggest that subdivision of tumor extension and node metastasis further improves the TNM-8th for PTC.

37. Drug Repositioning in the Treatment of Anaplastic Carcinoma of the Thyroid

H Noguchi¹, S Uchino², S Yokoyama³, T Murakami⁴

^1–4Noguchi Thyroid Clinic and Hospital Foundation, Japan

Introduction

Materials and methods

Results

Conclusion

38. Overview of Current Trends in Thyroid Surgery in Sri Lanka

MDP Pinto¹, DMCD Dissanayake², R Fernando³

^1–3Department of Surgery, Faculty of Medicine, University of Kelaniya, Sri Lanka

Introduction

Materials and methods

Results

Conclusion

39. Better Access to RAI and Advent of TKI Improved Outcome of Patients with Distant Metastasis from PTC

I Sugitani¹, A Ishikawa², K Toda³, H Mitani⁴, R Nagaoka⁵, M Saitou⁶, M Sen⁷, H Kazusaka⁸, M Matsui⁹

^1–9Department of Endocrine Surgery, Nippon Medical School and Division of Head and Neck, Cancer Institute Hospital, Tokyo, Japan

Purpose/Introduction

Materials and methods

Results

Conclusion

40. Predictive Factors of Recurrence for BMPTMC: A Single Center Study of 1,207 Chinese Patients

Shuai Xue¹, Li Zhang², Bingfei Dong³, Qiang Zhang⁴, Guang Chen⁵

^1,3–5Department of Thyroid Surgery, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China²Department of Nephrology, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China