World Journal of Endocrine Surgery

Register      Login

VOLUME 10 , ISSUE 2 ( May-August, 2018 ) > List of Articles


Thyroid Malignancy and Suicide Risk: An Analysis of Epidemiologic and Clinical Factors

Nathaniel J Walsh, Asif M Talukder, Andrew G Lawson, Amel X Komic, Brian P Bateson, Andrew J Jones, Edward J Kruse

Keywords : Mortality, Standardized mortality ratio, Suicide, Surveillance epidemiology and end results database, Thyroid cancer.

Citation Information : Walsh NJ, Talukder AM, Lawson AG, Komic AX, Bateson BP, Jones AJ, Kruse EJ. Thyroid Malignancy and Suicide Risk: An Analysis of Epidemiologic and Clinical Factors. World J Endoc Surg 2018; 10 (2):99-102.

DOI: 10.5005/jp-journals-10002-1227

License: CC BY-NC 4.0

Published Online: 01-07-2007

Copyright Statement:  Copyright © 2018; The Author(s).


Aim: To date, there has been no specific examination of suicide rates and factors associated with suicide in thyroid cancer. The aim of this study is to examine suicide incidence and associated factors in thyroid cancer patients from 1973 to 2013. Materials and methods: The Surveillance, Epidemiology, and End Results (SEER) database of the National Cancer Institute was queried to identify patients with thyroid cancer from 1973 to 2013. Comparison data with the general US population were derived from the Centers for Disease Control and Prevention's (CDC) National Center for Injury Prevention and Control using the Web-based Injury Statistics Query and Reporting System (WISQARS). Standardized mortality ratios (SMRs) and multivariable logistic regression models generated odds ratios (ORs) for the identification of factors associated with suicide. Results: Overall, 154 suicides among 168,339 patients were identified. There was no statistically significant difference in suicide rate with respect to age, marital status, median household income, surgical intervention, stage at diagnosis, or histologic subtype. On multivariable analysis male gender and Caucasian race were associated with increased risk of suicide with ORs of 5.39 and 3.17 respectively. Conclusion: Race and gender appear to influence suicide rates in patients with thyroid cancer. Females and whites were more likely to commit suicide as noted previously. There was no statistically significant relationship between suicide and marital status, income, mode of radiation therapy, and the role of surgical intervention. These results, coupled with further studies and analyses, could be used to formulate a comprehensive suicide risk factor scoring system for screening all cancer patients. Clinical significance: Thyroid cancer is very treatable with excellent long-term survival and outcomes. Improved screening and risk factor stratification in these patients could decrease the incidence of suicide in thyroid cancer patients.

PDF Share
  1. Vigneri R, Malandrino P, Vigneri P. The changing epidemiology of thyroid cancer: why is incidence increasing? Curr Opin Oncol 2015 Jan;27(1):1-7.
  2. Misono S, Weiss NS, Fann JR, Redman M, Yueh B. Incidence of suicide in persons with cancer. J Clin Oncol 2008 Oct;26(29):4731-4738.
  3. Cole TB, Bowling JM, Patetta MJ, Blazer DG. Risk factors for suicide among older adults with cancer. Aging Ment Health 2014 Sep;18(7):854-860.
  4. Johnson TV, Garlow SJ, Brawley OW, Master VA. Peak window of suicides occurs within the first month of diagnosis: implications for clinical oncology. Psychooncology 2012 Apr;21(4):351-356.
  5. Easley J, Miedema B, Robinson L. It's the “good” cancer, so who cares? Perceived lack of support among young thyroid cancer survivors. Oncol Nurs Forum 2013 Nov;40(6): 596-600.
  6. Roerink SH, de Ridder M, Prins J, Huijbers A, de Wilt HJ, Marres H, Repping-Wuts H, Stikkelbroeck NM, Timmers HJ, Hermus AR, et al. High level of distress in long-term survivors of thyroid carcinoma: results of rapid screening using the distress thermometer. Acta Oncol 2013 Jan;52(1):128-137.
  7. Lubitz CC, Kong CY, McMahon PM, Daniels GH, Chen Y, Economopoulos KP, Gazelle GS, Weinstein MC. Annual financial impact of well-differentiated thyroid cancer care in the United States. Cancer 2014 May;120(9):1345-1352.
  8. Aschebrook-Kilfoy B, James B, Nagar S, Kaplan S, Seng V, Ahsan H, Angelos P, Kaplan EL, Guerrero MA, Kuo JH, et al. Risk factors for decreased quality of life in thyroid cancer survivors: initial findings from the North American Thyroid Cancer Survivorship Study. Thyroid 2015 Dec; 25(12):1313-1321.
  9. Ramsey SD, Bansal A, Fedorenko CR, Blough DK, Overstreet KA, Shankaran V, Newcomb P. Financial insolvency as a risk factor for early mortality among patients with cancer. J Clin Oncol 2016 Mar;34(9):980-986.
  10. Harari A, Li N, Yeh MW. Racial and socioeconomic disparities in presentation and outcomes of well-differentiated thyroid cancer. J Clin Endocrinol Metab 2014 Jan;99(1):133-141.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.