World Journal of Endocrine Surgery

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VOLUME 10 , ISSUE 2 ( May-August, 2018 ) > List of Articles

CASE REPORT

Intrathyroidal Lymphoepithelial (Branchial) Cyst: Diagnostic and Management Challenge of a Rare Entity

Christos S Christoforides, Ioannis Papandrikos, Ilias Zorbas, Gerasimos Kritikos, Ioannis Pateras, Dimitrios Vlachodimitropoulos, Angelos Kalovidouris, Kyriakos Vamvakidis

Keywords : Branchial cyst, Case report, Intrathyroidal, Lymphoepithelial cyst, Rare, Thyroid cyst

Citation Information : Christoforides CS, Papandrikos I, Zorbas I, Kritikos G, Pateras I, Vlachodimitropoulos D, Kalovidouris A, Vamvakidis K. Intrathyroidal Lymphoepithelial (Branchial) Cyst: Diagnostic and Management Challenge of a Rare Entity. World J Endoc Surg 2018; 10 (2):137-141.

DOI: 10.5005/jp-journals-10002-1233

License: CC BY-NC 4.0

Published Online: 01-08-2018

Copyright Statement:  Copyright © 2018; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Intrathyroidal lymphoepithelial (branchial) cysts are very rare, and only few cases have been previously reported worldwide. Here, we report on a case of a male patient with such a rare histological finding after a routine left hemithyroidectomy performed for a nearly 4 cm cystic left thyroid lobe lesion. The patient was an 80-year-old man, fact that makes, to our knowledge, our patient the oldest in the current literature. Through a review of the existing literature, we concluded that although some entities are extremely rare, they should also be taken under consideration in everyday clinical differential diagnosis of otherwise common medical cases, such as our presented case. Such cases pose a differential dilemma for the clinical doctor in order to make a correct diagnosis, if that is possible, and then proceed with the efficient treatment.


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  1. Giunta J, Cataldo E. Lymphoepithelial cysts of the oral mucosa. Oral Surg 1973 Jan;35(1):77-84.
  2. Weidner N, Geisinger KR, Sterling RT, Miller TR, Yen TS. Benign lymphoepithelial cysts of the parotid gland: a histologic, cytologic, and ultrastructural study. Am J Clin Pathol 1986 Apr;85(4):395-401.
  3. Truong LD, Rangdaeng S, Jordan PH Jr. Lymphoepithelial cyst of the pancreas. Am J Surg Pathol 1987 Nov;11(11):899-903.
  4. Apel RL, Asa SL, Chalvardjian A, LiVolsi VA. Intrathyroidal lymphoepithelial cysts of probable branchial origin. Hum Pathol 1994 Nov;25(11):1238-1242.
  5. Delabie J, De Wolf-Peeters C, Cappelle L, Van Damme B, Desmet V. Branchial cleft like cysts of the thyroid. Am J Surg Pathol 1990;14:1165-1171.
  6. Haba R, Miki H, Kobayashi S, Kushida Y, Saoo K, Hirakawa E, Ohmori M. Intrathyroidal branchial cleft-like cyst in chronic thyroiditis. Pathol Int 2000 Nov;50(11):897-900.
  7. Lim-Tio SW, Judson R, Busmanis I, Zajac JD. An intrathyroidal branchial cyst: a case report. Aust N Z J Surg 1992 Oct;62(10):826-828.
  8. Ryska A, Vokurka J, Michal M, Ludvikova M. Intrathyroidal epithelial cyst: a report of two cases not associated with Hashimoto's thyroiditis. Pathol Res Pract 1997 Dec;193(11-12): 777-781.
  9. Louis DN, Vickery AL Jr, Rosai J, Wang CA. Multiple branchial cleft-like cysts in Hashimoto's thyroiditis. Am J Surg Pathol 1989 Jan;13(1):45-49.
  10. Carter E, Ulusarac O. Lymphoepithelial cysts of the thyroid gland: a case report and review of the literature. Arch Pathol Lab Med 2003 Apr;127(4):e205-e208.
  11. Ahuja AT, Chang AR, To E, Pang P, Ching AS, King AD, Metreweli C. Intrathyroidal lymphoepithelial (Branchial) cyst: sonographic features of a rare lesion. AJNR Am J Neuroradiol 2000 Aug;21(7):1340-1343.
  12. Kondi-Pafiti A, Kontogianni KI, Smyrniotis V, Voros D. Intrathyroid lymphoepithelial (branchial) cyst. A report of two cases and review of the literature. Hellenic Arch Pathol 2002;16(1):31-35.
  13. Nakazawa T, Kondo T, Oishi N, Tahara I, Kasai K, Inoue T, Mochizuki K, Katoh R. Branchial cleft-like cysts involving 3 different organs: thyroid gland, thymus, and parotid gland. Medicine (Baltimore) 2015 Oct;94(42):e1758.
  14. Miyazaki M, Kiuchi S, Fujioka Y. Branchial cleft-like cysts in Hashimoto's thyroiditis: a case report and literature review. Pathol Int 2016 May;66(5):297-301.
  15. Srbecka K, Michalova K, Curcikova R, Michal M Jr, Dubova M, Svajdler M, Michal M, Daum O. Spectrum of lesions derived from branchial arches occurring in the thyroid: from solid cell nests to tumors. Virchows Arch 2017 Sep;471(3): 393-400.
  16. Lee HJ, Kim EK, Hong S. Sonographic detection of intrathyroidal branchial cleft cyst: a case report. Korean J Radiol 2006 Apr-Jun;7(2):149-151.
  17. LiVolsi VA, Merino MJ. Squamous cells in the human thyroid gland. Am J Surg Pathol 1978 Jun;2(2):133-140.
  18. Williams ED, Toyn CE, Harach HR. The ultimobranchial gland and congenital thyroid abnormalities in man. J Pathol 1989 Oct;159(2):135-141.
  19. Harach HR. Solid cell nests of the thyroid. J Pathol 1988 Jul;155(3):191-200.
  20. Beckner ME, Shultz JJ, Richardson T. Solid and cystic ultimobranchial body remnants in the thyroid. Arch Pathol Lab Med 1990 Oct;114(10):1049-1052.
  21. Yamaoka Y. Solid cell nest (SCN) of the human thyroid gland. Acta Pathol Jpn 1973 Aug;23(3):493-506.
  22. Wtanabe I, Kobayashi K, Yamaguchi M, Kasai M. Multilocular lymphoepithelial cyst in the thyroid accompanied with a minute thyroid carcinoma. Pathol Int 1995 Dec;45(12): 965-970.
  23. Cho JS, Shin SH, Kim HK, Lee JS, Park MH, Yoon JH, Jegal YJ. Primary papillary carcinoma originated from a branchial cleft cyst. J Korean Surg Soc 2011 Dec;81(Suppl 1): S12-S16.
  24. Ruhl DS, Sheridan MF, Sniezek JC. Papillary thyroid carcinoma in a branchial cleft cyst without a thyroid primary: navigating a diagnostic dilemma. Case Rep Otolaryngol 2013 Jul;2013:405342.
  25. Gollahalli PK, Chikkannaiah P, Annam V. Primary papillary carcinoma of the thyroid arising in a branchial cyst: case report and review of the literature. Ear Nose Throat J 2013 Feb;92(2):E3-E5.
  26. Carney JA. Thyroid cysts. Am J Surg Pathol 1989 Dec; 13(12):1072-1074.
  27. Radhi JM, Clive PJ. Intrathyroidal branchial cleft cyst in Hashimoto's thyroiditis. AJR Am J Roentgenol 1994 Jul;163(1):229.
  28. Asanuma K, Nishio A, Itoh N, Kasuga Y, Amano J. Multiple branchial cleft-like cysts in a female patient with Hashimoto's thyroiditis. Endocr J 2000 Jun;47(3):303-307.
  29. Cassarino DS, Milas M, Folpe AL. Bilateral intrathyroidal lymphoepithelial cysts. Arch Pathol Lab Med 2003 Feb;127(2):251-252.
  30. Park JY, Kim GY, Suh YL. Intrathyroidal branchial cleft-like cyst with heterotopic salivary gland-type tissue. Pediatr Dev Pathol 2004 May-Jun;7(3):262-267.
  31. Michal M, Mukensnabl P, Kazakov DV. Branchial-like cysts of the thyroid associated with solid cell nests. Pathol Int 2006 Mar;56(3):150-153.
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