Cortisol and Aldosterone Co-secreting Tumors: A Diagnostic Challenge

Roma Pradhan; Suneel Mattoo; Sushil Gupta

doi:10.5005/jp-journals-10002-1251

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Cortisol and Aldosterone Co-secreting Tumors: A Diagnostic Challenge

Roma Pradhan, Suneel Mattoo, Sushil Gupta

Keywords : Adrenal, Hyperaldosteronism, Hypercortisolism

Citation Information : Pradhan R, Mattoo S, Gupta S. Cortisol and Aldosterone Co-secreting Tumors: A Diagnostic Challenge. World J Endoc Surg 2019; 11 (1):28-30.

DOI: 10.5005/jp-journals-10002-1251

License: CC BY-NC 4.0

Published Online: 01-12-2018

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Abstract

The unique subtype of co-secreting adrenal tumor especially aldosterone and cortisol co-secreting tumors presents a special challenge because they present with unexplained clinical constellations, may display unique laboratory test results, and impact postoperative care. Here, we describe three cases of co-secreting adrenal tumor. All our three cases had initial diagnosis of hypercortisolism with atypical features like muscle weakness and hypokalemia which led us to evaluate for hyperaldosteronism. Therefore, we suggest that patients of overt or subclinical Cushing's syndrome who have atypical features should be screened for hyperaldosteronism and similarly patients with primary hyperaldosteronism, especially those with a larger tumor size (>2.5 cm), should be screened for hypercortisolism to avoid postoperative adrenal crisis.

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