World Journal of Endocrine Surgery

Register      Login

VOLUME 11 , ISSUE 1 ( January–April, 2019 ) > List of Articles


Cortisol and Aldosterone Co-secreting Tumors: A Diagnostic Challenge

Roma Pradhan, Suneel Mattoo, Sushil Gupta

Keywords : Adrenal, Hyperaldosteronism, Hypercortisolism

Citation Information : Pradhan R, Mattoo S, Gupta S. Cortisol and Aldosterone Co-secreting Tumors: A Diagnostic Challenge. World J Endoc Surg 2019; 11 (1):28-30.

DOI: 10.5005/jp-journals-10002-1251

License: CC BY-NC 4.0

Published Online: 01-04-2019

Copyright Statement:  Copyright © 2019; The Author(s).


The unique subtype of co-secreting adrenal tumor especially aldosterone and cortisol co-secreting tumors presents a special challenge because they present with unexplained clinical constellations, may display unique laboratory test results, and impact postoperative care. Here, we describe three cases of co-secreting adrenal tumor. All our three cases had initial diagnosis of hypercortisolism with atypical features like muscle weakness and hypokalemia which led us to evaluate for hyperaldosteronism. Therefore, we suggest that patients of overt or subclinical Cushing's syndrome who have atypical features should be screened for hyperaldosteronism and similarly patients with primary hyperaldosteronism, especially those with a larger tumor size (>2.5 cm), should be screened for hypercortisolism to avoid postoperative adrenal crisis.

  1. Hiraishi K, Yoshimoto T, et al. Clinicopathological features of primary aldosteronism associated with subclinical Cushing's syndrome. Endocr J 2011;58(7):543–551.
  2. Hogan MJ, Schambelan M, et al. Concurrent hypercortisolism and hypermineralocorticoidism. Am J Med 1977;62:777–782.
  3. Späth M, Korovkin S, et al. Aldosterone- and cortisol-co-secreting adrenal tumors: the lost subtype of primary aldosteronism. Eur J Endocrinol 2011;164:447–455. DOI: 10.1530/EJE-10-1070.
  4. Vicennati V, Repaci A, et al. Combined aldosterone and cortisol secretion by adrenal incidentaloma. Int J Surg Pathol 2012;20:316–319. DOI: 10.1177/1066896911427036.
  5. Yamada M, Nakajima Y, et al. KCNJ5 mutations in aldosterone- and cortisol-co-secreting adrenal adenomas. Endocr J. 2012;59(8):735-741.
  6. Nakajima Y, Yamada M, et al. Cardiovascular complications of patients with aldosteronism associated with autonomous cortisol secretion. J Clin Endocrinol Metab 2011;96:2512–2518. DOI: 10.1210/jc.2010-2743.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.