World Journal of Endocrine Surgery

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VOLUME 12 , ISSUE 2 ( May-August, 2020 ) > List of Articles


The Missing Link between Ki-67 and Papillary Thyroid Carcinoma

Shahrun Niza Abdullah Suhaimi, Mohamad Aznan Shuhaili, Nurismah Md Isa, Suria Hayati Md Puad, Shamsul Azhar Shah, Rohaizak Mohammad

Citation Information : Suhaimi SN, Shuhaili MA, Isa NM, Puad SH, Shah SA, Mohammad R. The Missing Link between Ki-67 and Papillary Thyroid Carcinoma. World J Endoc Surg 2020; 12 (2):80-85.

DOI: 10.5005/jp-journals-10002-1287

License: CC BY-NC 4.0

Published Online: 03-04-2021

Copyright Statement:  Copyright © 2020; The Author(s).


Introduction: Ki-67 antigen was originally defined by the prototype monoclonal antibody Ki-67 detected by immunizing mice with nuclei of the Hodgkin lymphoma cell line L-428.2 The name derived from Kiel (city of origin) and the number of the original clone in the 96-well plate. Ki-67 has been thoroughly investigated in cases of both benign and malignant thyroid nodules. However, few previous studies have focused on a potential link between prognostic factors of papillary thyroid carcinoma (PTC) and the Ki-67 proliferative index. The objective of this study was to determine the prognostic significance of Ki-67 levels and PTC. We compared Ki-67 levels against the metastasis, age, completeness of resection, invasion, and size (MACIS) tumor scoring system. By correlating Ki-67 with poor prognostic features of thyroid carcinoma, we aimed to predict tumor recurrence in PTC. Materials and methods: A total of 46 PTC patients who had underwent surgery from 2006 to 2012 were involved in this study. All of the surgical specimens were analyzed for Ki-67 through immunohistochemistry (IHC), and two independent pathologists evaluated the Ki-67 staining results. We compared Ki-67 levels with various prognostic factors for PTC. Results: There was no significant relationship between the Ki-67 index and age, tumor size, cervical lymph nodes involvement, or complete tumor removal during initial surgery (p value > 0.05). However, there were significant links between Ki-67 levels and extrathyroidal extension (p value = 0.006), vascular invasion (p value = 0.006), and distant metastasis (p value = 0.005). Ki-67 was significantly reduced among the low-risk group for recurrent PTC (p value = 0.007). Tumor recurrence at 3 years was significantly correlated with high Ki-67 levels (p value = 0.01).

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