Endocrine-related Abnormalities in Locally Advanced Head and Neck Cancer Surgery Patients after Chemoradiation: A Myth or Mystery
Keywords :
Chemoradiation, Endocrine abnormalities, Head and neck cancer, Hypocalcemia, Hyponatremia, Hypothyroidism, Neck surgery
Citation Information :
Endocrine-related Abnormalities in Locally Advanced Head and Neck Cancer Surgery Patients after Chemoradiation: A Myth or Mystery. World J Endoc Surg 2022; 14 (3):69-72.
Patients with head and neck malignancy with locally advanced disease often require chemoradiation, and those patients who undergo chemoradiation encounter more endocrine/metabolic-related complications after surgery.
Materials and methods: We evaluated 36 locally advanced head and neck cancer patients who had undergone chemoradiation, followed by surgery during the period from February 2021 to June 2022 for various endocrine-related abnormalities, such as hyponatremia, hypokalemia, hypothyroidism, hypocalcemia, and complications associated with surgery in relation to these endocrine abnormalities.
Results: Among these 36 patients, 20 patients developed hyponatremia, four patients developed hypokalemia, and nine patients developed hypocalcemia at some point of time after the surgery, and their preoperative (pre-OP) values were normal. A total of 13 patients had subclinical hypothyroidism even before the surgery. Wound morbidity was more among these patients.
Conclusion: If all patients with head and neck cancers who are all undergoing surgery after chemoradiation are evaluated for electrolyte abnormalities, such as hyponatremia, hypocalcemia, and hypothyroidism, it may reduce the perioperative and postoperative (post-OP) complications and it may shorten the hospital stay, help in early recovery, and may avoid life-threatening conditions.
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