World Journal of Endocrine Surgery

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VOLUME 2 , ISSUE 1 ( January-April, 2010 ) > List of Articles


Jaw Tumor: An Uncommon Presenting Manifestation of Primary Hyperparathyroidism

Roy Phitayakorn, Christopher R McHenry

Citation Information : Phitayakorn R, McHenry CR. Jaw Tumor: An Uncommon Presenting Manifestation of Primary Hyperparathyroidism. World J Endoc Surg 2010; 2 (1):45-50.

DOI: 10.5005/jp-journals-10002-1021

Published Online: 01-12-2012

Copyright Statement:  Copyright © 2010; The Author(s).



To report two unusual cases of primary hyperparathyroidism (HPT) that initially manifested with a “ jaw tumor” and to discuss the clinical implications of a giant cell granuloma vs an ossifying fibroma of the jaw.

Material and methods

The history, physical examination, laboratory values and the imaging and pathologic findings are described in two patients who presented with a “jaw tumor” and were subsequently diagnosed with primary HPT. The diagnosis and management of osteitis fibrosa cystica and HPT-jaw tumor syndrome are reviewed.


Patient #1 was a 70-year-old male who presented with hypercalcemia, severe jaw pain, and an enlarging mass in his mandible. Biopsy of the mass revealed a giant cell tumor and he was subsequently diagnosed with primary HPT. A sestamibi scan demonstrated a single focus of abnormal radiotracer accumulation, corresponding to a 13,470 mg parathyroid adenoma, which was resected. Postoperatively, the serum calcium normalized and the giant cell granuloma regressed spontaneously.

Patient #2 was a 36-year-old male with four incidentally discovered tumors of the mandible and maxilla, who was diagnosed with normocalcemic HPT and vitamin D deficiency. Biopsy of one of the tumors revealed an ossifying fibroma. Bilateral neck exploration revealed a 2480 mg right inferior parathyroid adenoma, which was resected. Postoperative genetic testing revealed an HRPT2 gene mutation. He subsequently underwent resection of an enlarging ossifying fibroma of the mandible with secondary reconstruction.


A “jaw tumor” in a patient with primary HPT may be a manifestation of osteitis fibrosa cystica or HPT-jaw tumor syndrome underscoring the importance of biopsy and genetic testing for management and follow-up.

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