World Journal of Endocrine Surgery

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VOLUME 2 , ISSUE 2 ( May-August, 2010 ) > List of Articles


Molecular Basis of Primary Hyperparathyroidism

Peyman Björklund, Lee F Starker, Annabelle L Fonseca, Tobias Carling

Citation Information : Björklund P, Starker LF, Fonseca AL, Carling T. Molecular Basis of Primary Hyperparathyroidism. World J Endoc Surg 2010; 2 (2):63-70.

DOI: 10.5005/jp-journals-10002-1024

Published Online: 01-04-2013

Copyright Statement:  Copyright © 2010; The Author(s).


During the past decade and a half, studies of genetic predisposition, parathyroid tumorigenesis, and molecular genetics of familial hyperparathyroid disorders have started to unveil the molecular basis of pHPT. Primary HPT is found in several distinct disorders with autosomal dominant inheritance such as in multiple endocrine neoplasia type 1 (MEN1), MEN2A, the HPT-jaw tumor syndrome (HPT-JT), familial isolated hyperparathyroidism (FIHPT), autosomal dominant mild hyperparathyroidism (ADMH), and neonatal severe HPT (NSHPT).

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