World Journal of Endocrine Surgery

Register      Login

VOLUME 2 , ISSUE 2 ( May-August, 2010 ) > List of Articles


Metastatic Melanoma to Thyroid: A Case Report and Institutional Review

Gregory W Randolph, Carrie C Lubitz, William C Faquin, Randall D Gaz, Parangi Sareh, Richard A Hodin, Antonia E Stephen

Citation Information : Randolph GW, Lubitz CC, Faquin WC, Gaz RD, Sareh P, Hodin RA, Stephen AE. Metastatic Melanoma to Thyroid: A Case Report and Institutional Review. World J Endoc Surg 2010; 2 (2):97-100.

DOI: 10.5005/jp-journals-10002-1030

Published Online: 01-04-2013

Copyright Statement:  Copyright © 2010; The Author(s).



To report a case of melanoma metastatic to the thyroid gland and to review our experience with secondary neoplasms of the thyroid.


We depict the presentation and treatment of the patient, illustrating pathologic and radiologic findings. All patients with pathologic confirmation of metastatic tumors of the thyroid undergoing thyroidectomy at the Massachusetts General Hospital were reviewed (1995- 2008).


A 59-year-old male presented with malignant melanoma of the scalp. Two months following his melanoma excision and lymphadenectomy, he underwent a hemi-thyroidectomy for fine-needle aspirate positive solitary metastasis. He initially did well, but on follow-up was noted to have diffuse metastases and expired from his disease eight months following initial diagnosis. Institutional review revealed 13 additional patients with pathologically confirmed secondary thyroid tumors.


FNA remains an indispensable diagnostic tool. Palliation from local compressive symptoms is an indication for surgery and long-term survival is seen in some patients undergoing resection of isolated metastases.

PDF Share
  1. Cancer in Malmo 1958-1969. An autopsy study. Acta Pathol Microbiol Scand 1977;(Suppl)1-235.
  2. Metastatic tumors of the thyroid gland: A study of 79 cases in Chinese patients. Arch Pathol Lab Med 1998;122:37-41.
  3. Carcinoma of the thyroid in surgical and postmortem material. Analysis of 300 cases at autopsy and literature review. Ann Surg 1966;164:291-99.
  4. PET-associated incidental neoplasms of the thyroid. J Am Coll Surg 2008;207:259-64.
  5. Metastasis to the thyroid gland. A report of 43 cases. Cancer 1997;79:574-78.
  6. Metastasis of Carcinoma to the Thyroid Gland. Ann Surg 1964;160:169-77.
  7. Surgeon's role in the management of solitary renal cell carcinoma metastases occurring subsequent to initial curative nephrectomy: An institutional review. Ann Surg Oncol 1994;1:345-52.
  8. Clinically significant, isolated metastatic disease to the thyroid gland. World J Surg 199923177-80. discussion 181.
  9. Risk of malignancy in thyroid incidentalomas identified by fluorodeoxyglucosepositron emission tomography. Surgery 2001;130:941-46.
  10. Prevalence and risk of cancer of focal thyroid incidentaloma identified by 18Ffluorodeoxyglucose positron emission tomography for metastasis evaluation and cancer screening in healthy subjects. J Clin Endocrinol Metab 2003;88:4100-04.
  11. Management and prognosis of metastases to the thyroid gland. J Am Coll Surg 2005;200:203-07.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.