World Journal of Endocrine Surgery

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VOLUME 2 , ISSUE 3 ( September-December, 2010 ) > List of Articles


Thyroid Hemiagenesis and Papillary Carcinoma: A Rare Association

Tammaro P, Nunziante M, Del Prete M, Asciore L, Nappi F, Ge Lupoli, Lupoli Gi, Porcelli A, LA Marzano

Citation Information : P T, M N, M DP, L A, F N, Lupoli G, Gi L, A P, Marzano L. Thyroid Hemiagenesis and Papillary Carcinoma: A Rare Association. World J Endoc Surg 2010; 2 (3):145-147.

DOI: 10.5005/jp-journals-10002-1041

License: CC BY-NC 4.0

Published Online: 01-12-2010

Copyright Statement:  Copyright © 2010; The Author(s).


Hemiagenesis is the least frequent thyroid congenital anomaly. We report the case of a primary hypothyroidism due to thyroid hemiagenesis in a patient for whom, later on, a papillary carcinoma of the contralateral lobe was diagnosed. A child with known left lobe thyroid agenesis was found to have a 12 mm nodule in the right thyroid lobe during routine follow-up. Needle biopsy demonstrated the nodule to represent a papillary thyroid cancer and total thyroidectomy and lymphadenectomy of the central compartment was undertaken. Such event represents an extremely rare occurrence since there are only five other reports in literature that deal with a papillary carcinoma in a patient with thyroid hemiagenesis.

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  1. Revised American thyroid association management guidelines for patient with thyroid nodules and differentiated thyroid cancer. Thyroid 2009;19(11):1167-1201.
  2. Thyroid-specific gene expression in the multi-step process of thyroid carcinogenesis. Biochimie 1999;81(4):389-96.
  3. Molecular pathogenesis of thyroid nodules and cancer. Baillieres Best Pract Res Clin Endocrinol Metab 2000;14(4):517-39.
  4. Thyroid hemiagenesis associated with thyroid adenomatous hyperplasia and papillary thyroid carcinoma. Thyroid 2008;18(3):381-82.
  5. Thyroid hemiagenesis: Clinical significance in the patient with thyroid nodule. J Laryngol Otol 2006;120(7):605-07.
  6. Papillary adenocarcinoma in thyroid hemiagenesis. Head Neck 1992;14(4):312-15.
  7. Expression of Pax-8, p53 and bcl-2 in human benign and malignant thyroid diseases. Anticancer Res 2000;20(1A):311-26.
  8. Transcriptional activation of the thyroglobulin promoter directing suicide gene expression by thyroid transcription factor-1 in thyroid cancer cells. Cancer Res 2001;61(9):3640-46.
  9. Thyroid hemiagenesis and incidentally discovered papillary thyroid cancer: Case report and review of the literature. J Endocrinol 2005;28;66-71.
  10. Endocrine practice. May/June 2008; 14(4):465.
  11. Thyroid hemiagenesis associated with thyroid adenomatous hyperplasia and papillary thyroid carcinoma. Thyroid 2008;18(3).
  12. Thyroid hemiagenesis. Journal of surgical oncology 1997;68:137-40.
  13. The Updated American thyroid association guidelines for management of thyroid nodules and differentiated thyroid cancer: A surgical perspective Thyroid 2009;19(11).
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