World Journal of Endocrine Surgery

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VOLUME 2 , ISSUE 3 ( September-December, 2010 ) > List of Articles

CASE REPORT

Severe Hypercalcemia due to Primary Hyperparathyroidism with MEN 2A

Geoffrey B Thompson, Benzon M Dy, Bianca Vazquez, Peter J Tebben, Seema Kumar

Citation Information : Thompson GB, Dy BM, Vazquez B, Tebben PJ, Kumar S. Severe Hypercalcemia due to Primary Hyperparathyroidism with MEN 2A. World J Endoc Surg 2010; 2 (3):131-133.

DOI: 10.5005/jp-journals-10002-1037

Published Online: 01-12-2010

Copyright Statement:  Copyright © 2010; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Introduction

Severe hypercalcemia due to primary hyperparathyroidism (PHPT) is rare in the setting of MEN 2A.

Materials and methods

Two patients with MEN 2A and severe hypercalcemia were identified recently. Their clinical presentation, evaluation, surgical management and outcomes are reviewed.

Results

Two patients with MEN 2A were identified with severe hypercalcemia secondary to a parathyroid adenoma. Calcium levels were elevated to 12.7 mg/dL and 15.1 mg/dL, respectively (normal range = 8.9-10.1 mg/dL). In each case, a single parathyroid adenoma was identified and surgically excised with normalization of parathyroid and calcium levels postoperatively. Clinical manifestations at the time of diagnosis included constipation, polyuria, hypercalciuria, and decreased bone mineral density.

Conclusion

Severe elevation of serum calcium is a rare presentation of PHPT in MEN2A. The differential diagnosis should include parathyroid adenoma, hyperplasia and parathyroid carcinoma. Early surgical management is essential in the treatment of hyperparathyroidism with severe hypercalcemia to prevent further complications.


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