One of the three principal therapies of Graves' disease is radioiodine treatment. Hypothyroidism is considered as a treatment end point of successful radioiodine treatment for Graves' disease. The radioiodine-induced hypothyroidism is mostly irreversible. Though, early recurrences can be due to treatment failure, inadequate radioiodine dose or rarely due to Marine-Lenhart syndrome. Here, we report a rare case of recurrent Graves' disease, 3 years after successful radioiodine therapy induced hypothyroidism in a 50-year-old lady.
Cure rate after 131I therapy for hyperthyroidism. Acta Radiol 1981;20:161.
Radioiodine-induced hypothyroidism in Graves’ disease: Factors associated with the increasing incidence. J Nucl Med 1982;23:978.
Differences and similarities in the diagnosis and treatment of Graves’ disease in Europe, Japan and the United States. Thyroid 1991;1:129.
Long-term follow-up study of compensated low dose 131I therapy for Graves’ disease. N Engl J Med 1984;311:428.
Long-term results from graded low dose radioactive iodine therapy for thyrotoxicosis. Clin Endocrinol (Oxf) 1986;24:217.
Long-term follow-up study of radioiodine treatment of hyperthyroidism. Clin Endocrinol (Oxf) 2004;61:641-48.
Is calculation of the dose in radioiodine therapy of hyperthyroidism worthwhile? Clin Endocrinol (Oxf) 1995;43:325-29.
Usage of a fixed dose of radioactive iodine for the treatment of hyperthyroidism: One-year outcome in a regional hospital in Hong Kong. Hong Kong Med J 2009;15:267-73.
Radioactive iodine therapy in Graves’ hyperthyroidism: A prospective study from a teritiary referral centre in North India. JAPI 2005;53: 603-06.
The incidence of recurrence and hypothyroidism after radioiodine treatment in patients with hyperthyroidism in Trakya, a mild iodine deficiency area, during the period 1991-2003. Annals of Nuclear Medicine 2005;19(8): 737-42.
Coexistence of an autonomously functioning thyroid nodule in a patient with Graves’ disease: An unusual presentation of Marine-Lenhart syndrome. Endocr J 1997;44(4):571-74.
[Graves’ disease with associated thyroid nodules (nodular Graves’ disease). Clinical, diagnostic and therapeutic considerations]. An Med Interna 2003;20(8):403-09.
