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VOLUME 6 , ISSUE 1 ( January-April, 2014 ) > List of Articles


Carney Complex

Surendra Kumar Agarwal, Bipin Chandra

Citation Information : Agarwal SK, Chandra B. Carney Complex. World J Endoc Surg 2014; 6 (1):1-6.

DOI: 10.5005/jp-journals-10002-1138

Published Online: 01-08-2017

Copyright Statement:  Copyright © 2014; The Author(s).


How to cite this article

Majumdar G, Agarwal SK, Pande S, Chandra B. Carney Complex. World J Endoc Surg 2014;6(1):1-6.

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  1. ; Gordon, H.; Carpenter, PC.; Shenoy, BV.; Go, VL. The complex of myxomas, spotty pigmentation, and endocrine overactivity. Vol. 64. Baltimore: Medicine; 1985. p. 270-283.
  2. Baltimore, MD, USA: Johns Hopkins University. Available from: http://ominomorg.
  3. Clinical and molecular genetics of CNC. Best Pract Res Clin Endocrinol Metab 2010 Jun;24(3):389-399.
  4. Mutations in regulatory subunit type 1A of cyclic adenosine 5’-monophosphate-dependent protein kinase (PRKAR1A): phenotype analysis in 353 patients and 80 different genotypes. J Clin Endocrinol Metab 2009 Jun;94(6):2085-2091.
  5. A syndrome of various cutaneous pigmented lesions, myxoid neurofibroma and atrial myxoma: the NAME syndrome. Br J Dermatol 1980 Oct;103(4):421-429.
  6. Mucocutaneous lentigines, cardiomucocutaneous myxomas, and multiple blue nevi: the LAMB syndrome. J Am Acad Dermatol 1984 Jan;10(1):72-82.
  7. Clinical and molecular features of the CNC: diagnostic criteria and recommendations for patient evaluation. J Clin Endocrinol Metab 2001 Sep;86(9):4041-4046.
  8. CNC and the familial lentiginosis syndromes: link to inherited neoplasias and developmental disorders, and genetic loci. J Intern Med 1998 Jun;243(6):573-579.
  9. Epithelioid blue nevus and psammomatous melanotic schwannoma: the unusual pigmented skin tumors of the CNC. Semin Diagn Pathol 1998 Aug;15(3):216-224.
  10. Human tumors associated with CNC and germline PRKAR1A mutations: a protein kinase A disease! FEBS Lett 2003 Jul 3;546(1):59-64.
  11. Clinical and molecular genetics of CNC. Mol Genet Metab 2003 Feb;78(2):83-92.
  12. CNC, a familial multiple neoplasia and lentiginosis syndrome. Analysis of 11 kindreds and linkage to the short arm of chromosome 2. J Clin Invest 1996 Feb 1;97(3):699-705.
  13. Cyclic nucleotide dependant protein kinases. Pharmacol Ther 1991;50(1):123-145.
  14. Minireview: PRKAR1A: normal and abnormal functions. Endocrinology 2004 Dec;145(12):5452-5458.
  15. Analysis of the cAMP-dependant protein kinase system using molecular genetic approaches. Recent Prog Horm Res 1988;44:307-335.
  16. Phosphorylation-dephosphorylation of enzymes. Annu Rev Biochem 1979;48:923-939.
  17. Physiological substrates of cAMP-dependant protein kinase. Chem Rev 2001 Aug;101(8):2381-2411.
  18. PRKAR1A mutations and protein kinase A interactions with other signalling pathways in the adrenal cortex. J Clin Endocrinol Metab 2006 Jun;91(6):2380-2388.
  19. Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the CNC. Hum Mol Genet 2000 Dec 12;9(20):3037-3046.
  20. Mutations in the protein kinase A R1alpha regulatory subunit cause familial cardiac myxomas and CNC. J Clin Invest 2000 Sep;106(5):R31-R38.
  21. Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene in patients with CNC and primary pigmented nodular adrenocortical disease (PPNAD) reveals novel mutations and clues for pathophysiology. Am J Hum Genet 2002;71(6):1433.
  22. Mutations of the PRKAR1A gene in Cushing's syndrome due to sporadic primary pigmented nodular adrenocortical disease. J Clin Endocrinol Metab 2002 Sep;87(9):4324-4329.
  23. ; Liotta, L. The molecular basis of cancer. Philadelphia: WB Saunders; 1995. 574 p.
  24. Chromosome 2 (2p16) abnormalities in CNC tumours. J Med Genet 2003 Apr;40(4):268-277.
  25. Carney complex (CNC). Orphanet J Rare Dis 2006 Jun 6;1:21.
  26. Protein kinase A and its role in human neoplasia: the CNC paradigm. Endocr Relat Cancer 2004 Jun;11(2):265-280.
  27. CNC: the first 20 years. Curr Opin Oncol 2007 Jan;19(1):24-29.
  28. Carney complex and lentiginosis. Pigment Cell Melanoma Res 2009 Oct;22(5):580-587.
  29. Heterogeneity of skin manifestations in patients with CNC. J Am Acad Dermatol 2008 Nov;59(5):801-810.
  30. Familial Cushing's syndrome due to primary pigmented nodular adrenocortical disease. Reinvestigation 50 years later. N Engl J Med 1989 Dec 14;321(24):1659-1664.
  31. The complex of myxomas, spotty skin pigmentation and endocrine overactivity (CNC): imaging findings with clinical and pathological correlation. Insights Imaging 2013 Feb;4(1):119-133.
  32. The epithelioid blue nevus. A multicentric familial tumor with important associations, including cardiac myxoma and psammomatous melanotic schwannoma. Am J Surg Pathol 1996 Mar;20(3):259-272.
  33. Clinical and genetic analysis of primary bilateral adrenal diseases (micro- and macronodular disease) leading to Cushing's syndrome. Horm Metab Res 1998 Jun-Jul;30(6-7):456-463.
  34. Genetic and histologic studies of somatomammotropic pituitary tumors in patients with the “complex of spotty skin pigmentation, myxomas, endocrine overactivity and schwannomas” (Carney complex). J Clin Endocrinol Metab 2000 Oct;85(10):3860-3865.
  35. Cardiac myxomas. N Engl J Med 1995 Dec 14;333(24):1610-1617.
  36. Differences between nonfamilial and familial cardiac myxoma. Am J Surg Pathol 1985 Jan;9(1):53-55.
  37. Echocardiographic and pathologic characteristics of primary cardiac tumors: a study of 149 cases. Int J Cardiol 2002 Jul;84(1):69-75.
  38. Malignant tumors of the heart and great vessels: MR imaging appearance. Radiographics 1997 Jan-Feb;17(1):145-153.
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