World Journal of Endocrine Surgery

Register      Login

VOLUME 10 , ISSUE 2 ( May-August, 2018 ) > List of Articles

HOW I DO IT

Managing Adrenal Tumors in Children: Tricks and Tips

Roma Pradhan

Keywords : Adrenal tumor, Adrenocortical carcinoma, Pediatric.

Citation Information : Pradhan R. Managing Adrenal Tumors in Children: Tricks and Tips. World J Endoc Surg 2018; 10 (2):145-146.

DOI: 10.5005/jp-journals-10002-1235

License: CC BY-NC 4.0

Published Online: 01-10-2007

Copyright Statement:  Copyright © 2018; The Author(s).


Abstract

Adrenal tumors are extremely rare in childhood, except in Brazil, so that their clinical manifestations remain poorly known by pediatricians. In children, the most common manifestation of adrenal tumors is the appearance of pubic hair and other signs of virilization. Isolated androgen secretion is present in 40% of children's tumors vs 9% in adults. These tumors also have no reliable set of criteria for malignancy. Therefore, all suspected adrenal tumors must be managed as adrenocortical carcinomas (ACCs) until the final diagnosis is made. All children should be treated in endocrine oncologic centers with experienced endocrine surgeons in a highly interdisciplinary setting.


PDF Share
  1. Sabbaga CC, Avilla SG, Schulz C, Garbers JC, Blucher D. Adrenocortical carcinoma in children: clinical aspects and prognosis. J Pediatr Surg 1993 Jun;28(6):841-843.
  2. Sandrini R, Ribeiro RC, DeLacerda L. Childhood adrenocortical tumors. J Clin Endocrinol 1997 Jul;82(7):2027-2031.
  3. Icard P, Chapuis Y, Andreassian B, Bernard A, Proye C. Adrenocortical carcinoma in surgically treated patients: a retrospective study on 156 cases by the French Association of Endocrine Surgery. Surgery 1992 Dec;112(6):972-980.
  4. Luton JP, Cerdas B, Billaud L, Thomas G, Guilhaume B, Bertagna X, Laudat MH, Louvel A, Chapuis Y, Blondeau P, et al. Adrenocortical carcinoma: clinical features, prognostic factors and therapeutic results in 105 patients from a single center (1963–1987). N Engl J Med 1990 Apr;322(17):1195-1201.
  5. Papotti M, Libé R, Duregon E, Volante M, Bertherat J, Tissier F. The weiss score and beyond–histopathology for adrenocortical carcinoma. Horm Cancer 2011 Dec;2(6):333-340.
  6. Rodriguez-Galindo C, Figueiredo BC, Zambetti GP, Ribeiro RC. Biology, clinical characteristics, and management of adrenocortical tumors in children. Pediatr Blood Cancer 2005 Sep;45(3): 265-273.
  7. Wieneke JA, Thompson LD, Heffess CS. Adrenal cortical neoplasms in the pediatric population: a clinicopathologic and immunophenotypic analysis of 83 patients. Am J Surg Pathol 2003 Jul;27(7):867-881.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.