World Journal of Endocrine Surgery

Register      Login

VOLUME 13 , ISSUE 1 ( January-April, 2021 ) > List of Articles

CASE REPORT

Adrenal Ganglioneuroma: Presentation, Radiology, Histopathology, and Management

Liam A McMorrow, Jessika Voll, Andrew Elsaify, Wael Elsaify

Keywords : Adrenal tumor, Adrenalectomy, Ganglioneuroma

Citation Information : McMorrow LA, Voll J, Elsaify A, Elsaify W. Adrenal Ganglioneuroma: Presentation, Radiology, Histopathology, and Management. World J Endoc Surg 2021; 13 (1):28-31.

DOI: 10.5005/jp-journals-10002-1317

License: CC BY-NC 4.0

Published Online: 20-11-2021

Copyright Statement:  Copyright © 2021; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim and objective: Ganglioneuromas (GNs) are rare, benign tumors arising at peripheral autonomic ganglion sites. Their diagnosis is challenging and typically reliant on a histopathological diagnosis. We present two case studies of adrenal GN managed within our department alongside a review of the literature concerning the diagnosis and management of these unusual entities. Materials and methods: We documented the presentation, investigation, and management of two patients with adrenal GN. Additionally, we conducted a literature review based on searching PubMed utilizing the term “adrenal ganglioneuroma”. Results: Both patients presented with an incidental indeterminate adrenal mass on imaging and underwent further laboratory investigations, abdominal ultrasound, computed tomography, and magnetic resonance imaging. In both cases, laparoscopic adrenalectomy was performed with specimens demonstrating adrenal GN on histopathological analysis. Our literature review further demonstrated the infrequency of these lesions and the difficulty involved in their diagnosis. Conclusion: Ganglioneuroma occurs rarely in the adrenal gland usually without preceding clinical symptoms. Diagnosis is challenging and care must be taken to exclude malignant neuroblastoma and ganglioblastoma.


PDF Share
  1. Majbar A, Al E. Imaging of adrenal ganglioneuroma: a case report. BMC Res Notes 2014(7):791. DOI: 10.1186/1756-0500-7-791.
  2. Barzon L, Sonino N, Fallo F, et al. Prevalence and natural history of adrenal incidentalomas. Eur J Endocrinol 2003;149(4):273–285. DOI: 10.1530/eje.0.1490273.
  3. Zhou Y, Liang Q, Ou W-T, et al. Laparoscopic resection of primary adrenal ganglioneuroma: a case report and review of the literature. Oncol Lett. 2015;9(5):2167–2170. DOI: 10.3892/ol.2015.3021.
  4. Lucas K, Gula MJ, Knisely AS, et al. Catecholamine metabolites in ganglioneuroma. Med Pediatr Oncol 1994;22(4):240–243. DOI: 10.1002/mpo.2950220405.
  5. Jung HR, Kang K-J, Kwon JH, et al. Adrenal ganglioneuroma with hepatic metastasis. J Korean Surg Soc 2011;80(4):297. DOI: 10.4174/jkss.2011.80.4.297.
  6. Garvin JH, Lack EE, Berenberg W, et al. Ganglioneuroma presenting with differentiated skeletal metastases. Report of a case. Cancer 1984;54(2):357–360. DOI: 10.1002/1097-0142(19840715)54:2<357::AID-CNCR2820540230>3.0.CO;2-4.
  7. Lora MS, Waguespack SG, Moley JF, et al. Adrenal ganglioneuromas in children with multiple endocrine neoplasia type 2: a report of two cases. J Clin Endocrinol Metab 2005;90(7):4383–4387. DOI: 10.1210/jc.2004-2526.
  8. Geraci AP, de Csepel J, Shlasko E, et al. Ganglioneuroblastoma and ganglioneuroma in association with neurofibromatosis type I: report of three cases. J Child Neurol 1998;13(7):356–358. DOI: 10.1177/088307389801300712. http://www.ncbi.nlm.nih.gov/pubmed/9701489. Accessed November 12, 2016.
  9. Lonergan GJ, Schwab CM, Suarez ES, et al. Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation. Radiographics 2002;22(4):911–934. DOI: 10.1148/rg.232025146.
  10. Zhang Y, Nishimura H, Kato S, et al. MRI of ganglioneuroma: histologic correlation study. J Comput Assist Tomogr. 25(4):617–623. DOI: 10.1097/00004728-200107000-00018. http://www.ncbi.nlm.nih.gov/pubmed/11473195. Accessed November 12, 2016.
  11. Ichikawa T, Ohtomo K, Araki T, et al. Ganglioneuroma: computed tomography and magnetic resonance features. Br J Radiol 1996;69(818):114–121. DOI: 10.1259/0007-1285-69-818-114.
  12. Geoerger B, Hero B, Harms D, et al. Metabolic activity and clinical features of primary ganglioneuromas. 2001(10):1905–1913. DOI: 10.1002/1097-0142(20010515)91:103.0.co;2-4.
  13. WHO Classification of Tumours of the Central Nervous System. World Health Organization; 2007.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.