World Journal of Endocrine Surgery

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VOLUME 15 , ISSUE 3 ( September-December, 2023 ) > List of Articles

Original Article

Evaluation of Ultrasound Characteristics and Serum TSH Level in Predicting Malignancy among Patients Undergoing Thyroidectomy with FNAC-proven Diagnosis of Multinodular Goiter and Follicular Neoplasia: A Prospective Observational Study

Channa VK Rao, Vijayendra Kedage, Bharath S Veerabhadrappa, Rajgopal S Kallya

Keywords : Multinodular goiter, Follicular neoplasia, Fine needle aspiration cytology, Thyroid stimulating hormone level, Ultrasound of thyroid, Predictors of thyroid malignancy

Citation Information : Rao CV, Kedage V, Veerabhadrappa BS, Kallya RS. Evaluation of Ultrasound Characteristics and Serum TSH Level in Predicting Malignancy among Patients Undergoing Thyroidectomy with FNAC-proven Diagnosis of Multinodular Goiter and Follicular Neoplasia: A Prospective Observational Study. World J Endoc Surg 2023; 15 (3):59-62.

DOI: 10.5005/jp-journals-10002-1460

License: CC BY-NC 4.0

Published Online: 20-04-2024

Copyright Statement:  Copyright © 2023; The Author(s).


Background: Thyroid nodules are one of the most common diseases encountered in surgical practice. Predicting malignancy in patients with multinodular goiters (MNGs) becomes difficult due to the presence of multiple nodules. Targeting the nodule which might be malignant is of utmost importance. The task becomes difficult due to the presence of many different ultrasound scoring systems. This study aims to evaluate ultrasound characteristics and thyroid stimulating hormone (TSH) levels in predicting malignancy in patients with benign goiters and follicular neoplasia. Materials and methods: Our study was a prospective observational study that was conducted between April 2021 and September 2022. Patients aged 18 years and above with fine needle aspiration cytology (FNAC) suggestive of MNGs and follicular neoplasia were included in the study. Analysis of the variables was done by using statistical analysis in a social science application. Results: The final analysis was conducted on 106 patients who met the inclusion criteria. Ultrasound of the thyroid detected microcalcifications in 8.5% of patients, hypervascularity in 33%, solid components in 40.6%, and hypoechoic areas in 47.2% of the patients. The study showed that a TSH value of greater than 1.88 mIU/mL and solid components in ultrasonograph (USG) have high sensitivity and specificity in predicting malignancy. Conclusion: This study shows that ultrasound characteristics of microcalcifications, hypervascularity, solid component, and TSH level greater than 1.88 mIU/mL are statistically significant and can be fairly used for predicting malignancy in benign goiter and follicular neoplasia. The presence of these features may warrant a surgical excision to confirm the diagnosis, even if the FNAC is reported as benign.

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